Endocrine Abstracts

Glucocorticoids (Gcs) act through the ubiquitously expressed glucocorticoid receptor (GR). Transcriptional activation by the GR involves interaction with co-modulator proteins, the expression level of which can mediate Gc sensitivity. The aim of this study was to identify additional GR interacting proteins that may influence Gc sensitivity.Using a yeast two-hybrid screen we identified a novel GR interacting protein, R59, which showed an enhanced interact...

AMH, the fetal testicular sexual differentiative factor, is now implicated in adult ovarian function. Antral follicle immunohistochemistry demonstrated AMH protein and message, the staining peaking around 4 mm. Interestingly, AMH-knockout mice have increased FSH sensitivity. Our aim was to measure AMH in follicular fluid and cell-conditioned medium and AMHRII in normal ovaries from women undergoing TAH/BSO.Follicles were dissected intact, follicular flui...

Glucocorticoids (Gcs) exert their pleiotropic effects through activation of the ubiquitously expressed glucocorticoid receptor (GR). The mechanism of transcriptional activation by the GR involves interaction with co-modulator proteins. Glucocorticoid sensitivity is mediated by the expression level of these co-modulator proteins and GR concentration. Therefore, the aim of this study was to identify additional GR interacting proteins that may influence glucocorticoid sensitivity...

(This poster is based on OC29)...